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research article

Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives

Jessen, Henning J.
•
Barbaras, Damien
•
Hamburger, Matthias
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2009
Organic Letters

An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling l-tyrosinol-amide as the pharmacophore.

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Type
research article
DOI
10.1021/ol901277q
Web of Science ID

WOS:000268479900072

Author(s)
Jessen, Henning J.
•
Barbaras, Damien
•
Hamburger, Matthias
•
Gademann, Karl  
Date Issued

2009

Published in
Organic Letters
Volume

11

Issue

15

Start page

3446

End page

3449

Subjects

Alzheimers-Disease

•

Paecilomyces-Militaris

•

Carboxylic-Acids

•

Synapse Loss

•

Neurodegeneration

•

Pyridone

•

Metabolites

•

Aldehydes

•

Alcohols

•

Delivery

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSYNC  
Available on Infoscience
July 2, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/41022
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