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research article
Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives
2009
An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling l-tyrosinol-amide as the pharmacophore.
Type
research article
Web of Science ID
WOS:000268479900072
Author(s)
Date Issued
2009
Published in
Volume
11
Issue
15
Start page
3446
End page
3449
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
July 2, 2009
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