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research article

Astrocyte-neuron metabolic relationships: for better and for worse

Allaman, Igor  
•
Bélanger, Mireille  
•
Magistretti, Pierre J.  
2011
Trends in Neurosciences

In recent years, previously unsuspected roles of astrocytes have been revealed, largely owing to the development of new tools enabling their selective study in situ. These exciting findings add to the large body of evidence demonstrating that astrocytes play a central role in brain homeostasis, in particular via the numerous cooperative metabolic processes they establish with neurons, such as the supply of energy metabolites and neurotransmitter recycling functions. Furthermore, impairments in astrocytic function are increasingly being recognized as an important contributor to neuronal dysfunction and, in particular, neurodegenerative processes. In this review, we discuss recent evidence supporting important roles for astrocytes in neuropathological conditions such as neuroinflammation, amyotrophic lateral sclerosis and Alzheimer's disease. We also explore the potential for neuroprotective therapeutics based on the modulation of astrocytic functions.

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Type
research article
DOI
10.1016/j.tins.2010.12.001
Web of Science ID

WOS:000287833900003

Author(s)
Allaman, Igor  
•
Bélanger, Mireille  
•
Magistretti, Pierre J.  
Date Issued

2011

Publisher

Elsevier

Published in
Trends in Neurosciences
Volume

34

Issue

2

Start page

76

End page

87

Subjects

Amyotrophic-Lateral-Sclerosis

•

Spinal-Cord-Injury

•

Fibrillary Acidic Protein

•

Transgenic Mouse-Model

•

Traumatic Brain-Injury

•

Beta-Amyloid Peptides

•

Alzheimers-Disease

•

Reactive Astrocytes

•

Glial-Cells

•

Motor-Neurons

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNDC  
Available on Infoscience
April 29, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/66898
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