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research article
Development and diseases of the pancreas
2002
The pancreas is a vital gland of exocrine and endocrine function. It is the target of two main affections: diabetes and pancreatic cancer. We describe the tissue interactions, signaling pathways and intracellular targets that are involved in the emergence of the pancreas primordium and its proliferation, morphogenesis and differentiation. It appears that several genes of developmental relevance have an adult function and are involved in pancreas affections. Embryological experimentation in animals contributed to provide candidate genes for human disease and holds promise for future treatments.
Type
research article
Author(s)
Date Issued
2002
Published in
Volume
62
Issue
1
Start page
14
End page
23
Note
Review
CLIN GENET
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
June 13, 2006
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