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research article

Development and diseases of the pancreas

Johansson, K. A.
•
Grapin-Botton, A.  
2002
Clinical Genetics

The pancreas is a vital gland of exocrine and endocrine function. It is the target of two main affections: diabetes and pancreatic cancer. We describe the tissue interactions, signaling pathways and intracellular targets that are involved in the emergence of the pancreas primordium and its proliferation, morphogenesis and differentiation. It appears that several genes of developmental relevance have an adult function and are involved in pancreas affections. Embryological experimentation in animals contributed to provide candidate genes for human disease and holds promise for future treatments.

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Type
research article
DOI
10.1034/j.1399-0004.2002.620102.x
Author(s)
Johansson, K. A.
•
Grapin-Botton, A.  
Date Issued

2002

Published in
Clinical Genetics
Volume

62

Issue

1

Start page

14

End page

23

Subjects

cancer

•

diabetes

•

endoderm

•

gland

•

insulin

•

organogenesis

•

matrix metalloproteinase mmp-2

•

type-2 diabetes-mellitus

•

islet

•

endocrine-cells

•

homeobox gene isl-1

•

molecule n-cam

•

transgenic mice

•

exocrine pancreas

•

mouse pancreas

•

beta-cells

•

in-vitro

Note

Review

CLIN GENET

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPGRA  
Available on Infoscience
June 13, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/230496
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