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  4. Subtilin Production by Bacillus Subtilis: Stochastic Hybrid Models and Parameter Identification
 
research article

Subtilin Production by Bacillus Subtilis: Stochastic Hybrid Models and Parameter Identification

Cinquemani, E.
•
Porreca, R.
•
Ferrari-Trecate, G.
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2008
IEEE Transactions on Circuits and systems I: Regular papers and IEEE Transactions on Automatic Control

This paper presents methods for the parameter identification of a model of subtilin production by Bacillus subtilis. Based on a stochastic hybrid model, identification is split in two subproblems: estimation of the genetic network regulating subtilin production from gene expression data, and estimation of population dynamics based on nutrient and population level data. Techniques for identification of switching dynamics from sparse and irregularly sampled observations are developed and applied to simulated data. Numerical results are provided to show the effectiveness of our methods.

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Type
research article
DOI
10.1109/TAC.2007.911327
Author(s)
Cinquemani, E.
Porreca, R.
Ferrari-Trecate, G.
Lygeros, J.
Date Issued

2008

Published in
IEEE Transactions on Circuits and systems I: Regular papers and IEEE Transactions on Automatic Control
Volume

53

Issue

Special issue on systems biology

Start page

38

End page

50

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SCI-STI-GFT  
Available on Infoscience
January 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132627
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