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research article

A null model of the mouse whole-neocortex micro-connectome

Reimann, Michael W.
•
Geyaert, Michael
•
Shi, Ying  
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August 29, 2019
Nature Communications

In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale connectomics, studying connectivity between individual neurons. We combine these two complementary views of connectomics to build a first draft statistical model of the micro-connectome of a whole mouse neocortex based on available data on region-to-region connectivity and individual whole-brain axon reconstructions. This process reveals a targeting principle that allows us to predict the innervation logic of individual axons from meso-scale data. The resulting connectome recreates biological trends of targeting on all scales and predicts that an established principle of scale invariant topological organization of connectivity can be extended down to the level of individual neurons. It can serve as a powerful null model and as a substrate for whole-brain simulations.

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Type
research article
DOI
10.1038/s41467-019-11630-x
Web of Science ID

WOS:000483017900013

Author(s)
Reimann, Michael W.
Geyaert, Michael
Shi, Ying  
Lu, Huanxiang  
Markram, Henry  
Muller, Eilif  
Date Issued

2019-08-29

Publisher

Nature Research

Published in
Nature Communications
Volume

10

Article Number

3903

Subjects

Multidisciplinary Sciences

•

Science & Technology - Other Topics

•

electron-microscopy

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reconstruction

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connectivity

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tractography

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volume

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BBP-CORE  
LNMC  
Available on Infoscience
September 12, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/161085
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