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research article
Synthesis of asparagusic acid modified lysine and its application in solid-phase synthesis of peptides with enhanced cellular uptake
Tirla, Alina
•
Hansen, Moritz
•
Rivera-Fuentes, Pablo
2018
Cyclic disulfides, such as asparagusic acid, enhance the uptake of a variety of cargoes into live cells. Here, we report a robust and scalable synthesis of an asparagusic acid modified lysine. This amino acid can be used in solid-phase peptide synthesis. We confirmed that incorporation of this building block into the sequence of a peptide increases its cellular uptake substantially.
Type
research article
Authors
Tirla, Alina
•
Hansen, Moritz
•
Rivera-Fuentes, Pablo
Publication date
2018
Published in
Volume
29
Start page
1289
End page
1292
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 30, 2019
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