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  4. The spinal cord facilitates cerebellar upper limb motor learning and control; inputs from neuromusculoskeletal simulation
 
research article

The spinal cord facilitates cerebellar upper limb motor learning and control; inputs from neuromusculoskeletal simulation

Bruel, Alice Julie  
•
Abadia, Ignacio
•
Collin, Thibault Jean Etienne  
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January 1, 2024
Plos Computational Biology

Complex interactions between brain regions and the spinal cord (SC) govern body motion, which is ultimately driven by muscle activation. Motor planning or learning are mainly conducted at higher brain regions, whilst the SC acts as a brain-muscle gateway and as a motor control centre providing fast reflexes and muscle activity regulation. Thus, higher brain areas need to cope with the SC as an inherent and evolutionary older part of the body dynamics. Here, we address the question of how SC dynamics affects motor learning within the cerebellum; in particular, does the SC facilitate cerebellar motor learning or constitute a biological constraint? We provide an exploratory framework by integrating biologically plausible cerebellar and SC computational models in a musculoskeletal upper limb control loop. The cerebellar model, equipped with the main form of cerebellar plasticity, provides motor adaptation; whilst the SC model implements stretch reflex and reciprocal inhibition between antagonist muscles. The resulting spino-cerebellar model is tested performing a set of upper limb motor tasks, including external perturbation studies. A cerebellar model, lacking the implemented SC model and directly controlling the simulated muscles, was also tested in the same benchmark. The performances of the spino-cerebellar and cerebellar models were then compared, thus allowing directly addressing the SC influence on cerebellar motor adaptation and learning, and on handling external motor perturbations. Performance was assessed in both joint and muscle space, and compared with kinematic and EMG recordings from healthy participants. The differences in cerebellar synaptic adaptation between both models were also studied. We conclude that the SC facilitates cerebellar motor learning; when the SC circuits are in the loop, faster convergence in motor learning is achieved with simpler cerebellar synaptic weight distributions. The SC is also found to improve robustness against external perturbations, by better reproducing and modulating muscle cocontraction patterns.

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Type
research article
DOI
10.1371/journal.pcbi.1011008
Web of Science ID

WOS:001135884600001

Author(s)
Bruel, Alice Julie  
Abadia, Ignacio
Collin, Thibault Jean Etienne  
Sakr, Icare  
Lorach, Henri  
Luque, Niceto R.
Ros, Eduardo
Ijspeert, Auke  
Date Issued

2024-01-01

Publisher

Public Library Science

Published in
Plos Computational Biology
Volume

20

Issue

1

Article Number

e1011008

Subjects

Life Sciences & Biomedicine

•

Climbing Fibers

•

Purkinje-Cell

•

Short-Latency

•

Model

•

Modulation

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Movement

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Reflexes

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Act

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Cocontraction

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Stimulation

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BIOROB  
FunderGrant Number

European Union Human Brain Project Specific Grant Agreement 3

H2020-RIA. 945539

SPIKEAGE Spanish Ministry of Science and Innovation MCIN/AEI

PID2020-113422GA-I00

DLROB MCIN/AEI

TED2021-131294B-I00

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Available on Infoscience
February 20, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/204886
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