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research article
Sustained Effects of Nonallele-Specific Huntingtin Silencing
2009
Objective: Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated that RNA interference represents a promising approach for the treatment of autosomal dominant disorders. But whether an allele-specific silencing of mutant htt or a nonallele-specific silencing should be considered has not been addressed.
Type
research article
Web of Science ID
WOS:000264779600009
Authors
Drouet, Valerie
•
Perrin, Valerie
•
Hassig, Raymonde
•
Dufour, Noelle
•
Auregan, Gwennaelle
•
Alves, Sandro
•
Bonvento, Gilles
•
Brouillet, Emmanuel
•
•
Hantraye, Philippe
Publication date
2009
Publisher
Published in
Volume
65
Issue
3
Start page
276
End page
285
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 30, 2010
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