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research article

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2

Featherstone, M. S.
•
Baron, A.
•
Gaunt, S. J.
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1988
Proc Natl Acad Sci U.S.A

We have isolated a murine homeobox-containing gene, Hox-5.1, by virtue of its relatedness to the Hox-1.4 gene. In situ hybridization to metaphase spreads mapped Hox-5.1 to band D of mouse chromosome 2. Sequence comparisons indicate that Hox-5.1 is the murine homolog of the human C13 homeobox-containing gene. Hox-5.1 also bears significant similarity to the Xenopus Xhox-1A homeobox-containing gene and the Drosophila deformed homeotic gene at N-terminal and homeobox regions. Hox-5.1 transcripts were detected in mouse embryos, in adult mouse testis, kidney, heart, and intestine, and in mouse embryonal carcinoma cells treated with retinoic acid. In situ hybridization to sections from whole mouse embryos revealed Hox-5.1 expression in spinal cord and prevertebrae.

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Type
research article
DOI
10.1073/pnas.85.13.4760
Author(s)
Featherstone, M. S.
•
Baron, A.
•
Gaunt, S. J.
•
Mattei, M. G.
•
Duboule, D.  
Date Issued

1988

Published in
Proc Natl Acad Sci U.S.A
Volume

85

Issue

13

Start page

4760

End page

4

Note

Laboratoire de Genetique Moleculaire des Eucaryotes, Unite 184 de l'Institut National de la Sante et de la Recherche Medicale, Faculte de Medicine, Strasbourg, France.

Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPDUB  
Available on Infoscience
February 25, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/19121
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