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  4. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
 
research article

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

Lemaitre, B.  
•
Nicolas, E.
•
Michaut, L.
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1996
Cell

The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB). Here we demonstrate that these parallels extend to the immune response of Drosophila. In particular, the intracellular components of the dorsoventral signaling pathway (except for dorsal) and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults. We also show that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection. Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways.

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Type
research article
DOI
10.1016/S0092-8674(00)80172-5
Web of Science ID

WOS:A1996VJ44300015

PubMed ID

8808632

Author(s)
Lemaitre, B.  
Nicolas, E.
Michaut, L.
Reichhart, J. M.
Hoffmann, J. A.
Date Issued

1996

Publisher

Elsevier

Published in
Cell
Volume

86

Issue

6

Start page

973

End page

83

Subjects

Drosophila Proteins

•

Genes

•

Insect

•

Genes

•

MHC Class II

•

Insect Proteins

•

Receptors

•

Cell Surface

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPLEM  
Available on Infoscience
September 17, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53780
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