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  4. Tertiary Lymphoid Structures Generation Through Graph-Based Diffusion
 
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conference paper

Tertiary Lymphoid Structures Generation Through Graph-Based Diffusion

Madeira, Manuel  
•
Thanou, Dorina  
•
Frossard, Pascal  
Ahmadi, SA
•
Pereira, S
January 1, 2024
Graphs In Biomedical Image Analysis, And Overlapped Cell On Tissue Dataset For Histopathology, 5Th Miccai Workshop
5th International Workshop on Graphs in Biomedical Image Analysis (GRAIL) / Workshop on Overlapped Celi on Tissue - Cell Detection from Cell-Tissue Interaction Challenge (OCELOT) / 5th MICCAI Workshop / 1st MICCAI Challenge Workshop

Graph-based representation approaches have been proven to be successful in the analysis of biomedical data due to their capability of capturing intricate dependencies between biological entities, such as the spatial organization of different cell types in a tumor tissue. However, to further enhance our understanding of the underlying governing biological mechanisms, it is important to accurately capture the actual distributions of such complex data. Graph-based deep generative models are specifically tailored to accomplish that. In this work, we leverage state-of-the-art graph-based diffusion models to generate biologically meaningful cell-graphs. In particular, we show that the adopted graph diffusion model is able to accurately learn the distribution of cells in terms of their tertiary lymphoid structures (TLS) content, a well-established biomarker for evaluating the cancer progression in oncology research. Additionally, we further illustrate the utility of the learned generative models for data augmentation in a TLS classification task. To the best of our knowledge, this is the first work that leverages the power of graph diffusion models in generating meaningful biological cell structures.

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Type
conference paper
DOI
10.1007/978-3-031-55088-1_4
Web of Science ID

WOS:001212367700004

Author(s)
Madeira, Manuel  
•
Thanou, Dorina  
•
Frossard, Pascal  
Editors
Ahmadi, SA
•
Pereira, S
Date Issued

2024-01-01

Publisher

Springer International Publishing Ag

Publisher place

Cham

Published in
Graphs In Biomedical Image Analysis, And Overlapped Cell On Tissue Dataset For Histopathology, 5Th Miccai Workshop
ISBN of the book

978-3-031-55087-4

978-3-031-55088-1

Volume

14373

Start page

37

End page

53

Subjects

Technology

•

Deep Generative Models

•

Graph-Based Diffusion

•

Tertiary Lymphoid Structures

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS4  
Event nameEvent placeEvent date
5th International Workshop on Graphs in Biomedical Image Analysis (GRAIL) / Workshop on Overlapped Celi on Tissue - Cell Detection from Cell-Tissue Interaction Challenge (OCELOT) / 5th MICCAI Workshop / 1st MICCAI Challenge Workshop

Vancouver, CANADA

SEP 23-OCT 04, 2023

Available on Infoscience
June 19, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/208585
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