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  4. AC-Driven Aptamer-Decorated Graphene FET for Cortisol Detection
 
conference paper

AC-Driven Aptamer-Decorated Graphene FET for Cortisol Detection

Gilani, Ali  
•
Saeidi, Ali
•
Longo, Johan
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2024
Proceedings of IEEE Sensors
IEEE Sensors

Accurately measuring cortisol levels is crucial for diagnosing and managing stress-related conditions. Among all biofluids containing cortisol, Interstitial fluid (ISF) offers distinct advantages such as stable pH, continuous extraction, and minimal contamination risks. This study introduces a novel method utilizing an AC driven liquid-gate Graphene Field Effect Transistor (GFET) array device, decorated with a cortisol aptamer for precise cortisol detection from changes in GFETs' phase to address challenges encountered in DC measurements, including the Debye length screening effect and noise issues. Aptamers, selected for their compact size and ease of synthesis, serve as optimal recognition elements that also show capacitive changes. The proposed sensor demonstrates very strong linear detection ranges 1 nM to 1 μ M with sensitivity of 3.34 mV/dec (R2=0.94) for cortisol concentrations in 1XPBS. This effectively covers the physiological cortisol range in ISF, even in high ionic backgrounds. In this work, Graphene functionalization was validated using Raman spectroscopy and AFM-SNOM. The integration of AC voltage driven liquid-gate GFETs with aptamers shows promise for advancing 2D sensors in personalized healthcare technology. Keywords: GFET, graphene, aptamer, cortisol.

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Type
conference paper
DOI
10.1109/SENSORS60989.2024.10785129
Scopus ID

2-s2.0-85215263944

Author(s)
Gilani, Ali  

École Polytechnique Fédérale de Lausanne

Saeidi, Ali

Xsensio SA

Longo, Johan

Xsensio SA

Sprunger, Yann  

École Polytechnique Fédérale de Lausanne

Kamaei, Sadegh  

École Polytechnique Fédérale de Lausanne

Ameti, Adelina

Centre Hospitalier Universitaire Vaudois

Niederländer, Nicolas

Centre Hospitalier Universitaire Vaudois

Pitteloud, Nelly

Centre Hospitalier Universitaire Vaudois

Ionescu, Adrian M.  

École Polytechnique Fédérale de Lausanne

Date Issued

2024

Publisher

Institute of Electrical and Electronics Engineers Inc.

Published in
Proceedings of IEEE Sensors
ISBN of the book

9798350363517

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
NANOLAB  
Event nameEvent acronymEvent placeEvent date
IEEE Sensors

Kobe, Japan

2024-10-20 - 2024-10-23

Available on Infoscience
January 26, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/244597
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