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research article
Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols
A three-component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of a-substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford g-alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear-cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.
Type
research article
Web of Science ID
WOS:000354191600032
Authors
Publication date
2015
Publisher
Published in
Volume
54
Issue
18
Start page
5443
End page
5446
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 27, 2015
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