Increased data monitoring enables the energy-efficient operation of air-conditioning systems via data-mining. The latter is projected to have lesser consumption but more comprehensive diagnosis than traditional methods. Following the companion paper that proposed a systematic method for energy-saving potential calculations via data-mining, this article presents a detailed case study in an ice-storage air-conditioning system by employing the proposed method. Raw data were preprocessed prior to recognizing the constant- and variable-speed devices in the system. Classification and regression tree algorithms were utilized to identify the operating modes of the system. The regression models between the energy-consumption and operating-state parameters of the nine pumps and two chillers were fitted. Furthermore, the constraints pertaining to system operation were summarized. From the results, the particle swarm optimization method was applied to elucidate the benchmark energy cost and the consequent cost savings potential. The cost savings potential for the chiller plant room during the investigation duration of 59 d reached as high as 24.03%. The case study demonstrates the feasibility, effectiveness, and stability of the systematic approach. Further studies can facilitate the development of corresponding control strategies based on the potential analysis results, to investigate better optimization algorithm, and visualize the analysis process.