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  4. Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
 
research article

Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices

Sergi, Pier Nicola
•
del Valle, Jaume
•
Stieglitz, Thomas
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November 1, 2024
Applied Sciences-basel

The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data (R2=0.97), definitely improving on previous approaches.

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Type
research article
DOI
10.3390/app142210741
Web of Science ID

WOS:001366710700001

Author(s)
Sergi, Pier Nicola

Scuola Superiore Sant'Anna

del Valle, Jaume

University of Barcelona

Stieglitz, Thomas

University of Freiburg

Navarro, Xavier

CIBERNED

Micera, Silvestro  

École Polytechnique Fédérale de Lausanne

Date Issued

2024-11-01

Publisher

MDPI

Published in
Applied Sciences-basel
Issue

22

Article Number

10741

Subjects

neural implants

•

foreign body reaction

•

scar tissue

•

peripheral nerves

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
TNE  
FunderFunding(s)Grant NumberGrant URL

NEXTGENERATIONEU (NGEU)

PE0000006;1553 11.10.2022;THE (IECS00000017)-;GA-101099366-HORIZON-EIC-2022-PATHFINDEROPEN

Ministry of University and Research (MUR) National Recovery and Resilience Plan (NRRP)

Available on Infoscience
January 28, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/245748
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