A search for CP violation in the Cabibbo-suppressed D-0 K+K-+- decay mode is performed using an amplitude analysis. The measurement uses a sample of pp collisions recorded by the LHCb experiment during 2011 and 2012, corresponding to an integrated luminosity of 3.0 fb(-1). The D-0 mesons are reconstructed from semileptonic b-hadron decays into D0-X final states. The selected sample contains more than 160 000 signal decays, allowing the most precise amplitude modelling of this D-0 decay to date. The obtained amplitude model is used to perform the search for CP violation. The result is compatible with CP symmetry, with a sensitivity ranging from 1% to 15% depending on the amplitude considered.