This review presents an update describing binary and ternary semiconductors involving interfacial charge transfer (IFCT) in composites made up by TiO2, CuO, Ag2O and Fe2O3 used in microbial disinfection (bacteria and viruses). The disinfection mechanism, kinetics and generation of reactive oxygen species (ROS) in solution under solar/visible light are discussed. The surface properties of the photocatalysts and their active catalytic sites are described in detail. Pathogenic biofilm inactivation by photocatalytic thin films is addressed since biofilms are the most dangerous agents of spreading pathogens into the environment.