research article
Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligands
Pseudoproline-contg. peptide MeCO-Pro-Pro-Pro-Xaa-Pro-Val-Xaa-Pro-Pro-Pro-Pro-OH [Xaa = Ser(yProPh,H) = 2(S)-phenyloxazolidinyl-4-carboxylate] was synthesized and its conformation was examd. by CD spectroscopy. Its inhibition of the Grb2-SH3 domain was tested. [on SciFinder (R)]
Type
research article
Author(s)
Grell, Daniel
Tatsu, Yoshiro
Durieux, Patricia
Fernandez-Carneado, Jimena
Hengst, Beatrice
Kardinal, Christian
Feller, Stephan
Date Issued
2001
Publisher
Published in
Volume
40
Issue
15
Start page
2844
End page
2848
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
February 9, 2006
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