Synthesis of L-3-hydroxy-4-methoxy-5-methylphenylalanol
The L-3-hydroxy-4-methoxy-5-methylphenylalanol, a common subunit of ecteinascidin and safracin family alkaloids, was synthesized from L-tyrosine in eight steps with an overall yield of 50%. [on SciFinder (R)]
2009
3
466
468
CAN 150:515329
31-2
Alkaloids
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
60-18-4 (L-Tyrosine); 13139-17-8 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis); 262360-92-9P; 851915-13-4P; 1150635-46-3P; 1150635-53-2P; 1150635-56-5P; 1150635-60-1P; 1150635-61-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis); 686776-27-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis)
REVIEWED
OTHER