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research article

Sensing Protein Molecules Using Nanofabricated Pores

Han, A.
•
Schürmann, G.
•
Mondin, G.
Show more
2006
Applied Physics Letters

We report the detection of protein molecules with nanofabricated pores using the resistive pulse sensing method. A 20-nm -thick silicon nitride membrane with a nanofabricated pore measuring about 55 nm in diameter separated an electrolyte cell into two compartments. Current spike trains were observed when bovine serum albumin (BSA) was added to the negatively biased compartment. The magnitude of the spikes corresponded to particles 7-9 nm in diameter (the size of a BSA molecule) passing through the pore. This suggests that the current spikes were current blockages caused by single BSA molecules. The presented nano-Coulter counting method could be applied to detect single protein molecules in free solution, and to study the translocation of proteins through a pore. © 2006 American Institute of Physics.

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Type
research article
DOI
10.1063/1.2180868
Author(s)
Han, A.
•
Schürmann, G.
•
Mondin, G.
•
Bitterli, R. A.  
•
Hegelbach-Guye, N.
•
de Rooij, N. F.  
•
Staufer, U.
•
Hegelbach, N.G.
Date Issued

2006

Published in
Applied Physics Letters
Volume

88

Issue

9

Article Number

093901

Note

362

Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SAMLAB  
Available on Infoscience
May 12, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/39381
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