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  4. Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases
 
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Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases

Kavungal, Deepthy  
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Magalhães, Pedro  
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Kumar, Senthil T.  
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Fixler, Dror
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Wachsmann-Hogiu, Sebastian
2024
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
21 Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications

We introduce an infrared metasurface sensor based on plasmonic surface-enhanced infrared absorption spectroscopy combined with immunoassay, which detects alpha-synuclein, an early structural biomarker protein for neurodegenerative diseases with clinical specificity and identifies its different structural species using their unique spectroscopic signals. Unprecedentedly, we augmented the sensor with a Deep Neural Network, enabling quantitative differentiation of alpha-synuclein aggregates. Capable of multiplexing and retrieving aggregate signatures from complex biomatrix, our sensor shows promise for neurodegenerative disease diagnosis, disease progression monitoring, and drug efficacy assessment.

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