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research article

On-chip synthesis of fine-tuned bone-seeking hybrid nanoparticles

Hasani-Sadrabadi, Mohammad Mahdi
•
Dashtimoghadam, Erfan
•
Bahlakeh, Ghasem
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2015
Nanomedicine

Aims: Here we report a one-step approach for reproducible synthesis of finely tuned targeting multifunctional hybrid nanoparticles (HNPs). Materials & methods: A microfluidic-assisted method was employed for controlled nanoprecipitation of bisphosphonate-conjugated poly(D,L-lactide-co-glycolide) chains, while coencapsulating superparamagnetic iron oxide nanoparticles and the anticancer drug Paclitaxel. Results: Smaller and more compact HNPs with narrower size distribution and higher drug loading were obtained at microfluidic rapid mixing regimen compared with the conventional bulk method. The HNPs were shown to have a strong affinity for hydroxyapatite, as demonstrated in vitro bone-binding assay, which was further supported by molecular dynamics simulation results. In vivo proof of concept study verified the prolonged circulation of targeted microfluidic HNPs. Biodistribution as well as noninvasive bioimaging experiments showed high tumor localization and suppression of targeted HNPs to the bone metastatic tumor. Conclusion: The hybrid bone-targeting nanoparticles with adjustable characteristics can be considered as promising nanoplatforms for various theragnostic applications.

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Type
research article
DOI
10.2217/nmm.15.162
Web of Science ID

WOS:000366043000004

Author(s)
Hasani-Sadrabadi, Mohammad Mahdi
•
Dashtimoghadam, Erfan
•
Bahlakeh, Ghasem
•
Majedi, Fatemeh S.
•
Keshvari, Hamid
•
Van Dersarl, Jules J.
•
Bertsch, Arnaud  
•
Panahifar, Arash
•
Renaud, Philippe  
•
Tayebi, Lobat
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Date Issued

2015

Publisher

Future Medicine Ltd

Published in
Nanomedicine
Volume

10

Issue

23

Start page

3431

End page

3449

Subjects

bisphosphonate

•

hybrid nanoparticles

•

microfluidics platform

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LMIS4  
Available on Infoscience
February 16, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/123651
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