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  4. Electro-Mechanical Coupling in Human Atrial Cardiomyocytes: Model Development and Analysis of Inotropic Interventions
 
conference paper

Electro-Mechanical Coupling in Human Atrial Cardiomyocytes: Model Development and Analysis of Inotropic Interventions

Mazhar, Fazeelat
•
Regazzoni, Francesco
•
Bartolucci, Chiara
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January 1, 2021
2021 Computing In Cardiology (Cinc)
Conference on Computing in Cardiology (CinC)

Human-based computational models are a powerful tool that complements the experimental approaches and can improve our understanding of individual components of the heart by integrating them into one system. This paper aims to couple and calibrate a human atrial electromechanical model to analyse the coupling effects and inotropic interventions on human atrial electrophysiology, calcium dynamics, and active isometric contraction on a cellular scale. A human atrial electrophysiology model was coupled with one of the recently developed biophysically detailed contraction models. A collection of human atrial experimental data has been presented to calibrate the coupled model. The calibrated electro-mechanical human atrial model yielded action potential, calcium transient and active tension that were validated against the experiments and conclusions were drawn to explain the mismatch between in-silico and in-vitro experiments on inotropic interventions. The coupled and calibrated human atrial electromechanical model and simulation framework developed in this study serves as a pathway for future investigations of the effect of contractile performance and inotropic interventions on the electrophysiology of the atria.

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Type
conference paper
DOI
10.23919/CinC53138.2021.9662766
Web of Science ID

WOS:000821955000081

Author(s)
Mazhar, Fazeelat
Regazzoni, Francesco
Bartolucci, Chiara
Corsi, Cristiana
Dede, Luca
Quarteroni, Alfio  
Severi, Stefano
Date Issued

2021-01-01

Publisher

IEEE

Publisher place

New York

Published in
2021 Computing In Cardiology (Cinc)
ISBN of the book

978-1-6654-7916-5

Series title/Series vol.

Computing in Cardiology Conference

Subjects

Computer Science, Interdisciplinary Applications

•

Engineering, Biomedical

•

Computer Science

•

Engineering

•

mechanoelectric feedback

•

contraction

•

mechanisms

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
MATH  
Event nameEvent placeEvent date
Conference on Computing in Cardiology (CinC)

Brno, CZECH REPUBLIC

Sep 12-15, 2021

Available on Infoscience
August 1, 2022
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/189630
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