Sensation of reality refers to the ability of users to feel present in a multimedia experience. As 3D technologies target to provide more immersive and higher quality multimedia experiences, it is important to understand Quality of Experience (QoE) and sensation of reality. Recently, there have been efforts to measure brain activity in order to understand implicitly QoE for various multimedia contents. However, brain activity accounting for sensation of reality has not been adequately investigated. The goal of this paper is twofold. First, we investigate how various aspects, such as perceived quality, perceived depth, and content preference affect subjective sensation of reality through explicit subjective ratings. Second, we construct subjective classification systems to predict sensation of reality from multimedia experiences based on electroencephalography (EEG) and peripheral physiological signals such as heart rate and respiration.