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review article
Mycobacterial genome structure
1998
Genome maps have been constructed for the mycobacterial pathogens Mycobacterium leprae and Mycobacterium tuberculosis, as well as for the attenuated vaccine strain Mycobacterium bovis BCG Pasteur. While the chromosomes of M. tuberculosis and M. bovis BCG Pasteur show extensive conservation at the gross level, comparison with M. leprae revealed a high degree of diversification, with a mosaic-like pattern apparent. The ordered libraries of M. tuberculosis and M. leprae produced during the course of these studies played a central role in the genome sequencing projects of these two bacilli, showing the utility of this approach for systematic sequencing of bacterial genomes.
Type
review article
PubMed ID
9588804
Authors
Publication date
1998
Published in
Volume
19
Issue
4
Start page
573
End page
6
Subjects
Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
September 7, 2010
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