Ubiquitylation provides a means of targeting substrate proteins for degradation by the proteasome. Novel findings in C. elegans (Hoppe et al., 2004, this issue of Cell) establish that two ubiquitin-ligases team up to multiubiquitylate the myosin chaperone UNC-45, suggesting a novel link between regulated protein degradation and myosin assembly.
Type
research article
PubMed ID
15294151
Author(s)
Date Issued
2004
Published in
Volume
118
Issue
3
Start page
272
End page
274
Subjects
Note
ISREC (Swiss Institute for Experimental Cancer Research), 155, ch. des Boveresses, CH-1066 Epalinges/Lausanne.
Comment
Journal Article
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
August 24, 2006
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