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  4. Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells
 
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research article

Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells

Mukherjee, Sulagna  
•
Choi, Minji
•
Yun, Jong Won
December 24, 2022
Biotechnology And Bioprocess Engineering

Recently, adaptive non-shivering thermogenesis has attracted considerable attention because it can elevate energy expenditure and help treat obesity. Despite the numerous reports related to UCP1-driven thermogenesis, little is known regarding UCP1-independent thermogenesis in adipose tissues and muscle. Therefore, it is essential to identify the molecular targets for UCP1-independent thermogenesis and their mechanisms to increase the energy expenditure pharmacologically in both adipocytes and muscle. This study examined whether trans-anethole (TA), a major component of the essential oils of fennel, induces UCP1-independent SERCA/SLN-based thermogenesis and promotes the lipid metabolism in muscle cells. TA enhanced myogenesis, lipolysis, and the oxidative metabolism in C2C12 muscle cells. More importantly, TA activated the SERCA/SLN/RYR axis, thereby inducing thermogenesis in muscle cells. Molecular docking analysis revealed a good interaction between SERCA with TA with a strong bind activity. In conclusion, the current data unveiled a previously unknown mechanism of TA in myoblasts and suggests a possible therapeutic agent in muscles by enhancing energy expenditure.

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Type
research article
DOI
10.1007/s12257-022-0242-2
Web of Science ID

WOS:000903479700001

Author(s)
Mukherjee, Sulagna  
•
Choi, Minji
•
Yun, Jong Won
Date Issued

2022-12-24

Publisher

KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING

Published in
Biotechnology And Bioprocess Engineering
Volume

27

Start page

938

End page

948

Subjects

Biotechnology & Applied Microbiology

•

c2c12 muscle cells

•

obesity

•

thermogenesis

•

trans-anethole

•

ucp1-independent thermoigenesis

•

skeletal-muscle

•

energy-expenditure

•

essential oil

•

fat

•

metabolism

•

expression

•

sarcolipin

•

mechanism

•

creatine

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPSCHOONJANS  
Available on Infoscience
January 16, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/193755
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