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research article

Uncovering hidden in vivo resonances using editing based on localized TOCSY

Marjanska, Malgorzata
•
Henry, Pierre-Gilles
•
Bolan, Patrick J.
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2005
Magnetic Resonance in Medicine

A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of beta-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.

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Type
research article
DOI
10.1002/mrm.20425
Author(s)
Marjanska, Malgorzata
Henry, Pierre-Gilles
Bolan, Patrick J.
Vaughan, Brooks
Seaquist, Elizabeth R.
Gruetter, Rolf  
Uğurbil, Kâmil
Garwood, Michael
Date Issued

2005

Publisher

Wiley-Blackwell

Published in
Magnetic Resonance in Medicine
Volume

53

Issue

4

Start page

783

End page

9

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LIFMET  
Available on Infoscience
May 27, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/80937
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