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research article
High-field dissolution dynamic nuclear polarization of [1-C-13]pyruvic acid
[1-C-13]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-C-13] pyruvic acid, unextrapolated solution-state C-13 polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
Type
research article
Web of Science ID
WOS:000375689200002
Authors
•
•
Karlsson, Magnus
•
Lerche, Mathilde H.
•
Schwitter, Juerg
•
Publication date
2016
Publisher
Published in
Volume
18
Issue
18
Start page
12409
End page
12413
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
July 19, 2016
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