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  4. Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
 
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review article

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease

Oliveira, Luis M. A.
•
Gasser, Thomas
•
Edwards, Robert
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July 26, 2021
Npj Parkinsons Disease

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, alpha-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of alpha-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define alpha-synuclein's varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.

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s41531-021-00203-9.pdf

Type

Publisher's Version

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openaccess

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CC BY

Size

1.36 MB

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Adobe PDF

Checksum (MD5)

db771a24becd348b8e031706ad20fec2

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