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research article

Detecting single molecules launched for liquid surfaces in a time-of-flight mass spectrometer using ultraviolet and infrared lasers

Twerenbold, D.
•
Netuschill, A.
•
de Rooij, N. F.  
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2002
Proteomics

The launch of molecules from liquid surfaces in a time of flight mass spectrometer has been investigated using different sample preparation techniques, and by exposing the liquid samples to two different laser wavelengths, 337 nm from a N2 ultraviolet laser and 10.6 μm from a CO2 infrared laser. The molecules were detected with cryodetectors measuring the energy of the individual molecules. We present insulin and lysozyme results from samples introduced into the vacuum through a micromachined silicon injector, and from samples consisting of a glycerol droplet deposited directly on the sample holder at the high voltage stage of the ion optics.

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Type
research article
DOI
10.1002/1615-9861(200204)2:4<436::AID-PROT436>3.0.CO;2-I
Author(s)
Twerenbold, D.
•
Netuschill, A.
•
de Rooij, N. F.  
•
Luginbuhl, Ph.
•
Gerber, D.
•
Gritti, D.
•
Gonin, Y.
•
Rossel, F.
•
Vuilleumier, J.-L.
Date Issued

2002

Published in
Proteomics
Volume

2

Issue

4

Start page

436

End page

440

Note

288

Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SAMLAB  
Available on Infoscience
May 12, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/39960
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