Flavonoids are natural plant-derived compounds which have immense applications in pharmaceutical industry and have attracted the attention of both the industry and researchers involved in all fields of biology and medicine. Microbial production systems can act as efficient cell factories for flavonoid production due to their versatile genetic and metabolic capabilities which can produce a wide variety of flavonoids. Moreover, metabolic engineering and synthetic biology techniques are used to rewire the metabolic pathways of flavonoid production for enhancing the product yield. This chapter is presented as an update on the various engineering approaches to the microbial production of natural or synthetic flavonoids in heterologous microbial hosts.