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research article

Contextual suppression and protection in schizophrenic patients

Roinishvili, Maya
•
Chkonia, Eka
•
Brand, Andreas
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2008
European archives of psychiatry and clinical neuroscience

INTRODUCTION: Contextual processing is often strongly deteriorated in schizophrenic patients as found, for example, in higher cognitive as well as lower visual paradigms. In visual detection tasks, impoverished contextual facilitation was attributed to aberrant excitatory neural circuits. On the other hand, we found contextual suppression, possibly related to neural inhibition, to be fast and intact in a visual backward masking task. Here, we combine a suppressive with a "protective" paradigm to further our understanding of the contextual deficiencies of schizophrenic patients in visual information processing. METHODS: Twenty three schizophrenic patients and 18 healthy controls were asked to discriminate the offset direction of a vernier target, which was followed by one of a variety of masks for several stimulus onset asynchronies (SOAs). RESULTS: As in previous studies, patients needed clearly longer SOAs than controls. However, when longer SOAs were taken into account, increases as well as decreases in backward mask strength had comparable effects in patients and controls. CONCLUSIONS: From these results, we suggest that complex spatial processing is fast and intact in schizophrenic patients.

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Type
research article
DOI
10.1007/s00406-007-0780-9
Web of Science ID

WOS:000256967200002

Author(s)
Roinishvili, Maya
Chkonia, Eka
Brand, Andreas
Herzog, Michael H.  
Date Issued

2008

Publisher

Springer Verlag

Published in
European archives of psychiatry and clinical neuroscience
Volume

258

Issue

4

Start page

210

End page

6

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LPSY  
Available on Infoscience
March 23, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/48471
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