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research article

Investigation of hot roller embossing for microfluidic devices

Yeo, L.P.
•
Ng, S.H.
•
Wang, Z.F.
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2010
Journal of Micromechanics and Microengineering

Microfluidics for most bio-related diagnostic applications typically requires single usage disposable chips to avoid bio-fouling and cross-contamination. Individual piece-wise manufacturing of polymeric microfluidic devices has been widely employed in recent years. To significantly lower the manufacturing costs, one possible way is to improve the production yield of polymer microfluidic chips via the hot roller embossing method. This paper discusses the effects of varying the process parameters such as roller temperature, applied pressure and substrate preheating during hot roller embossing (according to a systematic set of experiment designs) and its influence on the corresponding mold to pattern fidelity in terms of normalized embossed depths on the poly (methylmethacrylate) (PMMA) substrate. Concurrently, pattern density studies on the mold were also conducted. Functional testing in terms of fluid flow and micromixing was carried out to evaluate the feasibility of using hot roller embossed PMMA substrates as microfluidic chips.

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Type
research article
DOI
10.1088/0960-1317/20/1/015017
Web of Science ID

WOS:000272922100017

Author(s)
Yeo, L.P.
•
Ng, S.H.
•
Wang, Z.F.
•
Xia, H.M.
•
Wang, Z.P.
•
Thang, V.S.
•
Zhong, Z.W.
•
de Rooij, N.F.  
Date Issued

2010

Published in
Journal of Micromechanics and Microengineering
Volume

20

Issue

1

Start page

015017

End page

015026

Subjects

Response-Surface Methodology

•

Nanoimprint Lithography

•

Polymer Flow

•

Design

•

Optimization

•

Fabrication

•

System

•

Replication

•

Electrodes

•

Delivery

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SAMLAB  
Available on Infoscience
January 21, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/45778
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