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research article
Cytotoxic effect of a polymer-copper(II) complex containing 2,2 '-bipyridyl ligand on human lung cancer cells
The cytotoxic activity of the polymer-copper(II) complex, [Cu(bpy)(2)(BPEI)]Cl-2 center dot 4H(2)O (bpy = 2,2'-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.
Type
research article
Web of Science ID
WOS:000291494300008
Authors
Kumar, R. Senthil
•
Periasamy, V. S.
•
Paul, C. Preethy
•
Riyasdeen, A.
•
Arunachalam, S.
•
Akbarsha, M. A.
Publication date
2011
Published in
Volume
20
Start page
726
End page
731
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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