Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Interactions in systems with short-range attractions and applications to protein crystallisation
 
research article

Interactions in systems with short-range attractions and applications to protein crystallisation

Lawlor, A.
•
McCullagh, G.D.
•
Zaccarell, E.
Show more
2004
Progress in Colloid and Polymer Science

The problem of phase behaviour of solutions of globular proteins is approached by means of a Hard Core Yukawa fluid model with short-ranged attractions. We have determined the phase behaviour of this model system for different well widths, using a variety of high quality methods. The essential phase behaviour of systems with short-ranged attractions is reproduced. The typical phase behaviour of solutions of globular proteins is well represented by the Hard Core Yukawa fluid with short-ranged attractions. The formation of amorphous precipitates in protein crystal growth experiments is identified on our model phase diagram with the formation of an attractive glass. As the range of attraction is decreased, the formation of an attractive glass state dominates the phase behaviour in the meta-stable regime above the critical point. We show how the addition of a long-ranged attraction, in the Two-Yukawa model, has the effect of eliminating the formation of attractive glass, while preserving the equilibrium features of the short-ranged attractive system. This opens the possibility of using attractive long-range interactions to avoid the formation of an attractive glass state.

  • Details
  • Metrics
Type
research article
DOI
10.1007/b11651
Author(s)
Lawlor, A.
McCullagh, G.D.
Zaccarell, E.
Foffi, G.  
Dawson, K.A.
Date Issued

2004

Published in
Progress in Colloid and Polymer Science
Volume

123

Start page

104

End page

109

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
GR-FO  
Available on Infoscience
January 28, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/46265
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés