This paper explores a novel approach for ventricular and atrial activities estimation in electrocardiogram (ECG) signals, based on sparse source separation. Sparse decompositions of ECG over signal-adapted multi-component dictionaries can lead to natural separation of its components. In this work, dictionaries of functions adapted to ventricular and atrial activities are respectively defined. Then, the weighted orthogonal matching pursuit algorithm is used to unmix the two components of ECG signals. Despite the simplicity of the approach, results are very promising, showing the capacity of the algorithm to generate realistic estimations of atrial and ventricular activities.