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research article

Events at the end of mitosis in the budding and fission yeasts

Simanis, V.  
2003
Journal of Cell Science

The mitotic exit network (MEN) and the septation initiation network (SIN) control events at the end of mitosis in S. cerevisiae and S. pombe, respectively. SIN initiates contraction of the actin ring and synthesis of the division septum, thereby bringing about cytokinesis. The MEN is also required for cytokinesis, but its main role is to control inactivation of mitotic cyclin-dependent kinases (CDKs) at the end of mitosis, and thereby regulate mitotic exit. Each revolves around a Ras-family GTPase and involves several protein kinases, and SIN and MEN proteins are localised to the spindle pole body. In S. cerevisiae, a second network, known as FEAR, cooperates with the MEN to bring about mitotic exit, and a third, AMEN, contributes to switching the MEN off. Some of the central components of the FEAR, SIN and MEN have been conserved through evolution, which suggests that aspects of their function in controlling events at the end of mitosis might be conserved in higher eukaryotes.

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Type
research article
DOI
10.1242/jcs.00807
Author(s)
Simanis, V.  
Date Issued

2003

Published in
Journal of Cell Science
Volume

116

Issue

Pt 21

Start page

4263

End page

75

Subjects

Actins/*metabolism

•

Fungal Proteins/metabolism

•

Gene Expression Regulation

•

Fungal

•

Microtubules

•

Mitosis/*physiology

•

Mitotic Spindle Apparatus/*metabolism

•

Protein Interaction Mapping

•

Saccharomyces cerevisiae/*cytology/metabolism

•

Schizosaccharomyces/*cytology/metabolism

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPSIM  
Available on Infoscience
October 21, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/30361
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