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research article
Sequencing by Hybridization of Long Targets
2012
Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.
Type
research article
PubMed ID
22574124
Authors
Publication date
2012
Published in
Volume
7
Issue
5
Article Number
e35819
Note
Editor: Gibas, Cynthia
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 7, 2015
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