research article
Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart
This study was performed to investigate the role of chronic pretreatment with angiotensin II type 1 receptor antagonists (ARB) and angiotensin converting enzyme inhibitors (ACE-I) in myocardial infarction (MI) and ischemic preconditioning (iPC). Little is known about molecular mechanisms of MI and iPC, especially about protein kinase C (PKC) isozyme levels induced by chronic pharmacologic pretreatment with ARB and ACE-I. To address one of the most important signal molecules in iPC, the PKC system was investigated in an ischemia/reperfusion model using isolated mouse hearts.
Type
research article
Author(s)
Lange, Stefan A.
Schober, Kristin
Wunderlich, Carsten
Marquetant, Rainer
Weinbrenner, Christof
Strasser, Ruth H.
Date Issued
2007
Published in
Volume
49
Issue
1
Start page
46
End page
55
Subjects
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
October 29, 2012
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