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  4. Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides
 
research article

Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides

Liu, Huizhen  
•
Lau, Genevieve P. S.  
•
Dyson, Paul J.  
2015
The Journal of Organic Chemistry

Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.

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Type
research article
DOI
10.1021/jo502412v
Web of Science ID

WOS:000347506400038

Author(s)
Liu, Huizhen  
Lau, Genevieve P. S.  
Dyson, Paul J.  
Date Issued

2015

Publisher

Amer Chemical Soc

Published in
The Journal of Organic Chemistry
Volume

80

Issue

1

Start page

386

End page

391

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
February 20, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/111288
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