Loading...
research article
Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
2013
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
Type
research article
Web of Science ID
WOS:000330158900015
Authors
Lehn, Van
•
Reid, C.
•
Atukorale, Prabhani U.
•
Carney, Randy P.
•
Yang, Yu-Sang
•
•
Irvine, Darrell J.
•
Alexander-Katz, Alfredo
Publication date
2013
Publisher
Published in
Volume
13
Issue
9
Start page
4060
End page
4067
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 17, 2014
Use this identifier to reference this record