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research article

Indicators of Evidence for Bioequivalence

Morgenthaler, Stephan  
•
Staudte, Robert
2016
Entropy

Some equivalence tests are based on two one-sided tests, where in many applications the test statistics are approximately normal. We define and find evidence for equivalence in Z-tests and then one-and two-sample binomial tests as well as for t-tests. Multivariate equivalence tests are typically based on statistics with non-central chi-squared or non-central F distributions in which the non-centrality parameter lambda is a measure of heterogeneity of several groups. Classical tests of the null lambda >= lambda(0) versus the equivalence alternative lambda < lambda(0) are available, but simple formulae for power functions are not. In these tests, the equivalence limit lambda(0) is typically chosen by context. We provide extensions of classical variance stabilizing transformations for the non-central chi-squared and F distributions that are easy to implement and which lead to indicators of evidence for equivalence. Approximate power functions are also obtained via simple expressions for the expected evidence in these equivalence tests.

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Type
research article
DOI
10.3390/e18080291
Web of Science ID

WOS:000382257800017

Author(s)
Morgenthaler, Stephan  
Staudte, Robert
Date Issued

2016

Publisher

Mdpi Ag

Published in
Entropy
Volume

18

Issue

8

Start page

291

Subjects

evidence for alternatives

•

Kullback-Leibler divergence

•

sample size determination

•

two by two tables

•

two one-sided tests

•

variance stabilization

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
STAP  
Available on Infoscience
October 18, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/130396
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