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  4. The switching threshold reconstruction problem for piecewise-affine models of genetic regulatory networks
 
research article

The switching threshold reconstruction problem for piecewise-affine models of genetic regulatory networks

Drulhe, S.
•
Ferrari-Trecate, G.
•
de Jong, H.
2008
IEEE Transactions on Circuits and systems I: Regular papers and IEEE Transactions on Automatic Control

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. We present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.

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Type
research article
DOI
10.1109/TAC.2007.911326
Author(s)
Drulhe, S.
Ferrari-Trecate, G.
de Jong, H.
Date Issued

2008

Published in
IEEE Transactions on Circuits and systems I: Regular papers and IEEE Transactions on Automatic Control
Volume

53

Issue

Special issue on systems biology

Start page

153

End page

165

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SCI-STI-GFT  
Available on Infoscience
January 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132626
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