Palladium nanohexagons were prepared using a seed-mediated method. Their catalytic performance in 2-methyl-3-butyn-2-ol hydrogenation was compared to the one of monodispersed Pd nanospheres. Quantitative correlations between initial turnover frequencies (TOFs) and nanoparticle surface compositions showed independence of TOFs calculated per atoms on Pd(111) facets on particle size and shape.