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research article

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Burtscher, Johannes  
•
Syed, Muhammed Muazzam Kamil  
•
Lashuel, Hilal A.  
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February 27, 2021
Movement Disorders

Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how neuroprotective effects can be induced by hypoxia conditioning and how related approaches have the potential to be harnessed as therapeutic strategies in Parkinson's disease. (C) 2021 International Parkinson and Movement Disorder Society

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Type
research article
DOI
10.1002/mds.28544
Web of Science ID

WOS:000622460200001

Author(s)
Burtscher, Johannes  
•
Syed, Muhammed Muazzam Kamil  
•
Lashuel, Hilal A.  
•
Millet, Gregoire P.
Date Issued

2021-02-27

Publisher

WILEY

Published in
Movement Disorders
Volume

36

Issue

4

Start page

857

End page

861

Subjects

Clinical Neurology

•

Neurosciences & Neurology

•

alpha-synuclein

•

conditioning

•

hypoxia

•

mitochondria

•

neurodegeneration

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LMNN  
Available on Infoscience
March 26, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/176351
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