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research article

Development of an enzyme fluidized bed reactor equipped with static mixers: application to lactose hydrolysis in whey

Fauquex, P.-F.
•
Flaschel, E.
•
Renken, A.  
1984
Chimia

Reactor operation with immobilized enzymes in fixed bed arrangement is often impaired due to the presence of finely divided solid matter, adsorbing substances or gas. The fluidized bed reactor would be applied in such cases owing to a limited pressure drop, a controlled voidage, and the avoidance of perforated plates for catalyst retention. Since enzymic reactions are often slow processes, catalysts of high external surface area should be provided together with sufficient time. However, classical fluidized beds suffer from hydrodynamic instability under these conditions. Therefore, a new reactor design was developed which used motionless mixers as internals. Fluidized bed reactors equipped with internals exhibit an outstanding hydrodynamic stability accompanied by an increase of the operating range in terms of flow rate by a factor of 4 compared to the classical fluidized bed. Results are presented, with emphasis on the backmixing and expansion characteristics. Various motionless mixers were investigated in columns of 39 and 150 mm in diam. The fluidized bed equipped with internals was used for lactose [63-42-3] hydrolysis in partially deproteinized whey. The lactase [9031-11-2] from Aspergillus niger immobilized on silica gel particles of 125-160 mm had a half-life of .apprx.1 mo. [on SciFinder (R)]

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Type
research article
Author(s)
Fauquex, P.-F.
•
Flaschel, E.
•
Renken, A.  
Date Issued

1984

Published in
Chimia
Volume

38

Issue

7-8

Start page

262

End page

269

Subjects

Whey (lactose hydrolysis in

•

with fluidized bed enzyme reactor); Reactors (fluidized-bed

•

with static mixers

•

lactose hydrolysis with)

•

reactor lactase lactose whey

Note

CAN 101:189709

16-8

Fermentation and Bioindustrial Chemistry

Inst. Genie Chim.,Ec. Polytech. Fed. Lausanne,Lausanne,Switz.

Journal

written in French.

63-42-3 Role: RCT (Reactant), RACT (Reactant or reagent) (hydrolysis of, in whey with fluidized bed reactor); 9031-11-2 Role: BIOL (Biological study) (immobilized, in fluidized bed reactor with static mixers)

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LGRC  
Available on Infoscience
April 18, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/229339
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