research article
Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes
2017
Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as reductant, and simple nickel salt and ligand as a catalyst system. The scope of amides includes both alkyl and aryl secondary amides, with high functional group compatibility.
Type
research article
Web of Science ID
WOS:000412795700078
Author(s)
Date Issued
2017
Publisher
Published in
Volume
7
Issue
10
Start page
7092
End page
7096
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
November 8, 2017
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