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  4. Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes
 
research article

Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes

Cheung, Chi Wai  
•
Ploeger, Marten Leendert  
•
Hu, Xile  
2017
Acs Catalysis

Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as reductant, and simple nickel salt and ligand as a catalyst system. The scope of amides includes both alkyl and aryl secondary amides, with high functional group compatibility.

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Type
research article
DOI
10.1021/acscatal.7b02859
Web of Science ID

WOS:000412795700078

Author(s)
Cheung, Chi Wai  
Ploeger, Marten Leendert  
Hu, Xile  
Date Issued

2017

Publisher

American Chemical Society

Published in
Acs Catalysis
Volume

7

Issue

10

Start page

7092

End page

7096

Subjects

transamidation

•

nickel catalysis

•

reductive coupling

•

amide synthesis

•

nitroarenes

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSCI  
Available on Infoscience
November 8, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/142020
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