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research article

Active axial stress in mouse aorta

Agianniotis, Aristotelis  
•
Rachev, Alexander  
•
Stergiopulos, Nikolaos  
2012
Journal of Biomechanics

The study verifies the development of active axial stress in the wall of mouse aorta over a range of physiological loads when the smooth muscle cells are stimulated to contract. The results obtained show that the active axial stress is virtually independent of the magnitude of pressure, but depends predominately on the longitudinal stretch ratio. The dependence is non-monotonic and is similar to the active stress-stretch dependence in the circumferential direction reported in the literature. The expression for the active axial stress fitted to the experimental data shows that the maximum active stress is developed at longitudinal stretch ratio 1.81, and 1.56 is the longitudinal stretch ratio below which the stimulation does not generate active stress. The study shows that the magnitude of active axial stress is smaller than the active circumferential stress. There is need for more experimental investigations on the active response of different types of arteries from different species and pathological conditions. The results of these studies can promote building of refined constrictive models in vascular rheology. (C) 2012 Elsevier Ltd. All rights reserved.

  • Details
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Type
research article
DOI
10.1016/j.jbiomech.2012.05.025
Web of Science ID

WOS:000307318300010

PubMed ID

22698830

Author(s)
Agianniotis, Aristotelis  
•
Rachev, Alexander  
•
Stergiopulos, Nikolaos  
Date Issued

2012

Publisher

Elsevier

Published in
Journal of Biomechanics
Volume

45

Issue

11

Start page

1924

End page

7

Subjects

Mechanical behavior

•

Active stress

•

Mouse aorta

•

Vascular smooth muscle cells

•

Biaxial active response

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LHTC  
Available on Infoscience
January 22, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/88048
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