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research article

Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters

Tschopp, Patrick
•
Fraudeau, Nadine
•
Béna, Frédérique
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2011
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)

The emergence of Vertebrata was accompanied by two rounds of whole-genome duplications. This enabled paralogous genes to acquire novel functions with high evolutionary potential, a process suggested to occur mostly by changes in gene regulation, rather than in protein sequences. In the case of Hox gene clusters, such duplications favored the appearance of distinct global regulations. To assess the impact of such "regulatory evolution" upon neo-functionalization, we developed PANTHERE (PAN-genomic Translocation for Heterologous Enhancer RE-shuffling) to bring the entire megabase-scale HoxD regulatory landscape in front of the HoxC gene cluster via a targeted translocation in vivo. At this chimeric locus, Hoxc genes could both interpret this foreign regulation and functionally substitute for their Hoxd counterparts. Our results emphasize the importance of evolving regulatory modules rather than their target genes in the process of neo-functionalization and offer a genetic tool to study the complexity of the vertebrate regulatory genome.

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Type
research article
DOI
10.1073/pnas.1102985108
Web of Science ID

WOS:000292251000053

Author(s)
Tschopp, Patrick
•
Fraudeau, Nadine
•
Béna, Frédérique
•
Duboule, Denis  
Date Issued

2011

Published in
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)
Volume

108

Issue

26

Start page

10632

End page

10637

Subjects

genetics

•

limb development

•

global gene regulation

•

long-range enhancers

•

mouse genetics

•

Global Control Region

•

Homeobox Gene

•

Expression

•

Mouse

•

Vertebrate

•

Limb

•

Complex

•

Mice

•

Duplications

•

Collinearity

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
UPDUB  
Available on Infoscience
June 23, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/68949
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